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    suox-1 Cytochrome b5 heme-binding domain-containing protein;sulfite oxidase [ Caenorhabditis elegans ]

    Gene ID: 181638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    suox-1
    Official Full Name
    Cytochrome b5 heme-binding domain-containing protein;sulfite oxidase
    Primary source
    WormBase:WBGene00010397
    Locus tag
    CELE_H13N06.4
    See related
    AllianceGenome:WB:WBGene00010397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heme binding activity; molybdopterin cofactor binding activity; and sulfite oxidase activity. Predicted to be involved in sulfur compound metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in inherited metabolic disorder and isolated sulfite oxidase deficiency. Orthologous to human SUOX (sulfite oxidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See suox-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (15497555..15500281)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene VWFA domain-containing protein Neighboring gene Trehalose-phosphatase Neighboring gene DOMON domain-containing protein;Tyramine beta-hydroxylase Neighboring gene Uncharacterized protein Neighboring gene Zinc transporter zipt-7.2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Obtaining the necessary molybdenum cofactor for sulfite oxidase activity in the nematode Caenorhabditis elegans surprisingly involves a dietary source. Oliphant KD, et al. J Biol Chem, 2023 Jan. PMID 36423681, Free PMC Article
    2. Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Warnhoff K, et al. Nat Chem Biol, 2019 May. PMID 30911177, Free PMC Article
    3. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
    4. Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Xia Q, et al. Redox Biol, 2023 Apr. PMID 36791646, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin cofactor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfite oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfite oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfur compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome b5 heme-binding domain-containing protein;sulfite oxidase
    NP_001024735.1
    • Confirmed by transcript evidence
    NP_001379385.1
    • Partially confirmed by transcript evidence
    NP_001379444.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15497555..15500281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392901.1 → NP_001379444.1  Cytochrome b5 heme-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q564P9
      Conserved Domains (1) summary
      pfam00173
      Location:85 → 157
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    2. NM_001392900.1 → NP_001379385.1  sulfite oxidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9XNE4
      Conserved Domains (2) summary
      cd02111
      Location:171 → 493
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:85 → 157
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    3. NM_001029564.7 → NP_001024735.1  sulfite oxidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024735.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XTQ8
      Conserved Domains (2) summary
      cd02111
      Location:178 → 539
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:85 → 157
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    Nucleotide Protein
    Heading Accession and Version

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