atp-1 ATP synthase subunit alpha, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atp-1
Official Full Name: ATP synthase subunit alpha, mitochondrial
Primary source: WormBase:WBGene00010419
Locus tag: CELE_H28O16.1
See related: AllianceGenome:WB:WBGene00010419
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables enterobactin binding activity. Involved in iron import into cell. Located in mitochondrion. Is expressed in several structures, including anal depressor muscle; body wall musculature; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22; mitochondrial complex V (ATP synthase) deficiency nuclear type 4A; and mitochondrial complex V (ATP synthase) deficiency nuclear type 4B. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See atp-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (12652277..12654655)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-208 (e-PCR)
- UniSTS:241700

H28O16.1 (e-PCR)
- UniSTS:312671

H28O16.2 (e-PCR)
- UniSTS:306835

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enterobactin binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in iron import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase subunit alpha, mitochondrial

NP_001021526.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

12652277..12654655

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026355.6 → NP_001021526.1 ATP synthase subunit alpha, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021526.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7K7K6, Q7YTU5, Q7YTU6, Q9XXK1

Conserved Domains (4) summary

PRK09281
Location:34 → 538

PRK09281; F0F1 ATP synthase subunit alpha; Validated

cd01132
Location:122 → 403

F1_ATPase_alpha; F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to ...

pfam00306
Location:412 → 516

ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain

pfam02874
Location:54 → 120

ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain