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    pak-2 Serine/threonine-protein kinase pak-2 [ Caenorhabditis elegans ]

    Gene ID: 179527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pak-2
    Official Full Name
    Serine/threonine-protein kinase pak-2
    Primary source
    WormBase:WBGene00006443
    Locus tag
    CELE_C45B11.1
    See related
    AllianceGenome:WB:WBGene00006443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in nematode larval development. Predicted to be active in cytoplasm. Is expressed in hypodermis; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pak-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (11036461..11039429, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ac108 Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system. Melzig J, et al. Curr Biol, 1998 Nov 5. PMID 9811608
    2. Genes implicated in Caenorhabditis elegans and human health regulate stress resistance and physical abilities in aged Caenorhabditis elegans. Dysarz J, et al. Biol Lett, 2021 Jun. PMID 34102068, Free PMC Article
    3. The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response. Fujiki K, et al. Mol Cell Biol, 2010 Feb. PMID 20008556, Free PMC Article
    4. The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance. Lucanic M, et al. Development, 2006 Nov. PMID 17050621
    5. Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids. Möller S, et al. Aging (Albany NY), 2020 Jul 7. PMID 32634117, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase pak-2
    NP_505809.2
    • Confirmed by transcript evidence
    NP_505810.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11036461..11039429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073409.7 → NP_505810.2  Serine/threonine-protein kinase pak-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505810.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFU0
      Conserved Domains (3) summary
      smart00220
      Location:230 → 480
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01093
      Location:14 → 60
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:221 → 481
      PKc_like; Protein Kinases, catalytic domain

    2. NM_073408.6 → NP_505809.2  Serine/threonine-protein kinase pak-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505809.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFU0, Q9U3M1
      Conserved Domains (3) summary
      smart00220
      Location:232 → 482
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01093
      Location:14 → 60
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:223 → 483
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFU0.1

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