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    C15C8.4 Alpha-2-macroglobulin RAP C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C15C8.4
    Official Full Name
    Alpha-2-macroglobulin RAP C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00007606
    Locus tag
    CELE_C15C8.4
    See related
    AllianceGenome:WB:WBGene00007606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heparin binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to be involved in regulation of receptor-mediated endocytosis. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system. Is expressed in head neurons; intestine; nerve ring neurons; and tail neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C15C8.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (12745201..12747463, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene PAS domain-containing protein cky-1 Neighboring gene ncRNA Neighboring gene Aspartic protease 10 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene Serpentine Receptor, class Z

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha-2-macroglobulin RAP C-terminal domain-containing protein
    NP_506187.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12745201..12747463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073786.8 → NP_506187.2  Alpha-2-macroglobulin RAP C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506187.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF26
      Conserved Domains (3) summary
      cd14803
      Location:223 → 230
      RAP; 3-helical coiled coil [structural motif]
      pfam06401
      Location:123 → 310
      Alpha-2-MRAP_C; Alpha-2-macroglobulin RAP, C-terminal domain
      cl05743
      Location:218 → 316
      RAP; Receptor-associated protein (RAP)
    Nucleotide Protein
    Heading Accession and Version

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