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    cdk-9 putative cyclin-dependent kinase 9 [ Caenorhabditis elegans ]

    Gene ID: 173023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdk-9
    Official Full Name
    putative cyclin-dependent kinase 9
    Primary source
    WormBase:WBGene00000410
    Locus tag
    CELE_H25P06.2
    See related
    AllianceGenome:WB:WBGene00000410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Involved in embryo development; germ cell development; and nematode larval development. Located in euchromatin. Is expressed in several structures, including germ line. Orthologous to human CDK9 (cyclin dependent kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdk-9 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (11323527..11333154)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Calpain catalytic domain-containing protein Neighboring gene Phosphotransferase Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization. Takagi T, et al. J Biol Chem, 2003 Apr 18. PMID 12576476
    2. RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans. Cassart C, et al. Sci Adv, 2020 Dec. PMID 33298437, Free PMC Article
    3. Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline. Bowman EA, et al. Development, 2013 Sep. PMID 23903194, Free PMC Article
    4. An RNAi screen for conserved kinases that enhance microRNA activity after dauer in Caenorhabditis elegans. Roka Pun H, et al. G3 (Bethesda), 2024 Mar 6. PMID 38226857, Free PMC Article
    5. CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Shim EY, et al. Genes Dev, 2002 Aug 15. PMID 12183367, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of RNA polymerase II is independent of cdk-9 in the C. elegans germline.
      Title: Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative cyclin-dependent kinase 9
    NP_492906.2
    • Confirmed by transcript evidence
    NP_492907.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11323527..11333154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060505.4 → NP_492906.2  putative cyclin-dependent kinase 9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492906.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TVL3, Q9XTH5
      Conserved Domains (2) summary
      smart00220
      Location:85 → 413
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07865
      Location:72 → 413
      STKc_CDK9; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9

    2. NM_060506.5 → NP_492907.2  putative cyclin-dependent kinase 9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492907.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TVL3
      Conserved Domains (2) summary
      smart00220
      Location:85 → 413
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07865
      Location:72 → 413
      STKc_CDK9; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TVL3.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.