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    ceh-43 Homeobox domain-containing protein;Homeobox protein ceh-43 [ Caenorhabditis elegans ]

    Gene ID: 175581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-43
    Official Full Name
    Homeobox domain-containing protein;Homeobox protein ceh-43
    Primary source
    WormBase:WBGene00000463
    Locus tag
    CELE_C28A5.4
    See related
    AllianceGenome:WB:WBGene00000463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in dopaminergic neuron differentiation and embryo development. Predicted to be located in nucleus. Is expressed in several structures, including ABalaa; ABalap; anterior hypodermis; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4; orofacial cleft 15; split hand-foot malformation 1; split hand-foot malformation 1 with sensorineural hearing loss; and trichodontoosseous syndrome. Orthologous to several human genes including DLX1 (distal-less homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-43 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (4446638..4449943, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene REJ domain-containing protein Neighboring gene Annexin Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans distal-less ortholog ceh-43 is required for development of the anterior hypodermis. Aspöck G, et al. Dev Dyn, 2001 Nov. PMID 11747075
    2. Exon duplication from a fork head to a homeodomain protein. Bürglin TR, et al. Dev Genes Evol, 1999 Oct. PMID 10552305
    3. Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans. Kaltenbach LS, et al. Dev Dyn, 2005 Oct. PMID 16127716
    4. Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity. Jimeno-Martín A, et al. Genome Res, 2022 Mar. PMID 35074859, Free PMC Article
    5. A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans. Doitsidou M, et al. Genes Dev, 2013 Jun 15. PMID 23788625, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox domain-containing protein;Homeobox protein ceh-43
    NP_001338832.1
    • Confirmed by transcript evidence
    NP_497904.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4446638..4449943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065503.5 → NP_497904.1  Homeobox protein ceh-43 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497904.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18273
      UniProtKB/TrEMBL
      Q95QC6
      Conserved Domains (1) summary
      pfam00046
      Location:105 → 158
      Homeobox; Homeobox domain

    2. NM_001351863.3 → NP_001338832.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RBT1, Q95QC6
      Conserved Domains (1) summary
      pfam00046
      Location:105 → 168
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18273.1

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