rnr-1 Ribonucleoside-diphosphate reductase large subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rnr-1
Official Full Name: Ribonucleoside-diphosphate reductase large subunit
Primary source: WormBase:WBGene00004391
Locus tag: CELE_T23G5.1
See related: AllianceGenome:WB:WBGene00004391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including hypodermis; intestine; nervous system; reproductive system; and somatic gonad precursor. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rnr-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (9225375..9228250, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATL-1 functions to maintain mtDNA independently of ribonucleotide reductase
Title: Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23G5.1 (e-PCR)
- UniSTS:308094

T23G5.3 (e-PCR)
- UniSTS:317148

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in deoxyribonucleotide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ribonucleoside-diphosphate reductase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ribonucleoside-diphosphate reductase large subunit

NP_001369835.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9225375..9228250 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382958.2 → NP_001369835.1 Ribonucleoside-diphosphate reductase large subunit [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03604

Conserved Domains (1) summary

PLN02437
Location:8 → 787

PLN02437; ribonucleoside--diphosphate reductase large subunit