uggt-1 UDP-Glucose Glycoprotein glucosylTransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: uggt-1
Official Full Name: UDP-Glucose Glycoprotein glucosylTransferase
Primary source: WormBase:WBGene00018604
Locus tag: CELE_F48E3.3
See related: AllianceGenome:WB:WBGene00018604
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables UDP-glucose:glycoprotein glucosyltransferase activity. Involved in IRE1-mediated unfolded protein response; protein N-linked glycosylation via asparagine; and regulation of nematode larval development. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including excretory secretory system; germ line; muscle cell; nervous system; and pharynx. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) and UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See uggt-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (7495694..7500982, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F48E3.3 (e-PCR)
- UniSTS:312339

F48E3.6 (e-PCR)
- UniSTS:314388

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucose:glycoprotein glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucose:glycoprotein glucosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables UDP-glucose:glycoprotein glucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UDP-glucosylation	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein N-linked glycosylation via asparagine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-Glucose Glycoprotein glucosylTransferase

NP_509268.1

Product from WormBase gene class uggt;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7495694..7500982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076867.5 → NP_509268.1 UDP-Glucose Glycoprotein glucosylTransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509268.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GPA0

Conserved Domains (2) summary

cd06432
Location:1202 → 1449

GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family

pfam06427
Location:22 → 1170

UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase