rtcb-1 RNA-splicing ligase RtcB homolog [Caenorhabditis elegans] - Gene

Summary

Official Symbol: rtcb-1
Official Full Name: RNA-splicing ligase RtcB homolog
Primary source: WormBase:WBGene00008877
Locus tag: CELE_F16A11.2
See related: AllianceGenome:WB:WBGene00008877
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA ligase (ATP) activity. Involved in IRE1-mediated unfolded protein response. Acts upstream of or within with a positive effect on germ cell development and vulval development. Located in cytoplasm and nucleus. Is expressed in body wall musculature; pharynx; and vulval muscle. Used to study Parkinson's disease. Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables RNA ligase (ATP) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity, forming phosphoric ester bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA-splicing ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA-splicing ligase complex	IEA Inferred from Electronic Annotation more info
part_of tRNA-splicing ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_492498.1

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The following sections contain reference sequences that belong to a specific genome build. Explain