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    mog-1 putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 [ Caenorhabditis elegans ]

    Gene ID: 176409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mog-1
    Official Full Name
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1
    Primary source
    WormBase:WBGene00003389
    Locus tag
    CELE_K03H1.2
    See related
    AllianceGenome:WB:WBGene00003389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5' RNA helicase activity and RNA binding activity. Involved in feminization of hermaphroditic germ-line. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Is expressed widely. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mog-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (9952060..9956215, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ovule protein Neighboring gene L-fucokinase domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Apoptosis-linked gene 2-interacting protein X 1 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22. Puoti A, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737793, Free PMC Article
    2. Sequenced Breakpoints of Crossover Suppressor/Inversion qC1. Edgley ML, et al. MicroPubl Biol, 2021. PMID 34746683, Free PMC Article
    3. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. van Haaften G, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15326288, Free PMC Article
    4. The C. elegans sex determination protein MOG-3 functions in meiosis and binds to the CSL co-repressor CIR-1. Kasturi P, et al. Dev Biol, 2010 Aug 15. PMID 20478293
    5. The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-Box protein family. Puoti A, et al. Mol Cell Biol, 1999 Mar. PMID 10022905, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in feminization of hermaphroditic germ-line IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1
    NP_499212.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9952060..9956215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066811.10 → NP_499212.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499212.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34498
      Conserved Domains (6) summary
      smart00487
      Location:437 → 620
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:840 → 922
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:458 → 596
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:622 → 778
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam07717
      Location:956 → 1056
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      pfam08648
      Location:114 → 239
      DUF1777; Protein of unknown function (DUF1777)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34498.2

    Gene LinkOut

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