wee-1.3 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: wee-1.3
Official Full Name: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3
Primary source: WormBase:WBGene00006940
Locus tag: CELE_Y53C12A.1
See related: AllianceGenome:WB:WBGene00006940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of meiotic cell cycle process involved in oocyte maturation; negative regulation of ovulation; and oocyte maturation. Acts upstream of or within nematode male tail tip morphogenesis. Located in several cellular components, including condensed chromosome; nuclear envelope; and perinuclear endoplasmic reticulum. Is expressed in several structures, including germ line; intestine; oocyte; somatic cell; and spermatheca. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See wee-1.3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (9713737..9716467, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions between the WEE-1.3 kinase and the PAM-1 aminopeptidase in oocyte maturation and the early C. elegans embryo.
Title: Interactions between the WEE-1.3 kinase and the PAM-1 aminopeptidase in oocyte maturation and the early C. elegans embryo.
results indicate that CDC-25.1 is required for maintaining proper rate of germline mitotic cell cycle; propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively controlling CDK-1
Title: CDC-25.1 controls the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively regulating CDK-1 in Caenorhabditis elegans.
Depletion of the Myt1 ortholog WEE-1.3 in C. elegans hermaphrodites causes precocious oocyte maturation in vivo.
Title: The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Y53C12A.1 (e-PCR)
- UniSTS:310308

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic nuclear membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of meiotic cell cycle process involved in oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of meiotic cell cycle process involved in oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ovulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of membrane	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3

NP_496095.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9713737..9716467 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063694.7 → NP_496095.1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496095.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18209

Conserved Domains (2) summary

smart00220
Location:108 → 355

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14050
Location:106 → 353

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1