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    fezf-1 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3564888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fezf-1
    Official Full Name
    C2H2-type domain-containing protein
    Primary source
    WormBase:WBGene00012639
    Locus tag
    CELE_Y38H8A.5
    See related
    AllianceGenome:WB:WBGene00012639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 22 with or without anosmia. Orthologous to several human genes including FEZF1 (FEZ family zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fezf-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (13466097..13469399)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Small muscular protein Neighboring gene ncRNA Neighboring gene non-specific serine/threonine protein kinase Neighboring gene non-specific serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the insulator protein CTCF during nematode evolution. Heger P, et al. BMC Mol Biol, 2009 Aug 27. PMID 19712444, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein
    NP_502594.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13466097..13469399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070193.5 → NP_502594.2  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502594.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62425
      Conserved Domains (4) summary
      COG5048
      Location:13 → 212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:54 → 74
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam11931
      Location:50 → 70
      DUF3449; Domain of unknown function (DUF3449)
      pfam13465
      Location:66 → 91
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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