spr-4 Suppressor of presenilin protein 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spr-4
Official Full Name: Suppressor of presenilin protein 4
Primary source: WormBase:WBGene00005009
Locus tag: CELE_C09H6.1
See related: AllianceGenome:WB:WBGene00005009
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in neurons. Used to study Alzheimer's disease and epilepsy. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spr-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (8103596..8109228)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In wild-type worms, overexpression of spr-4 suppresses excitation and extends lifespan. REST, SPR-3, SPR-4 and reduced excitation activate the longevity-associated transcription factors FOXO1 and DAF-16 in mammals and worms, respectively. These findings reveal a conserved mechanism of ageing that is mediated by neural circuit activity and regulated by REST.
Title: Regulation of lifespan by neural excitation and REST.
Data report the cloning and characterization of spr-3 and spr-4, which encode large basic zinc-finger proteins which act as transcriptional repressors for sel-12 [spr-3 and spr-4].
Title: Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C09H6.1 (e-PCR)
- UniSTS:307240

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Suppressor of presenilin protein 4

NP_001020993.1

Confirmed by transcript evidence

NP_001020994.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8103596..8109228

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025823.6 → NP_001020994.1 Suppressor of presenilin protein 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020994.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17582

Conserved Domains (1) summary

sd00017
Location:114 → 134

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001025822.4 → NP_001020993.1 Suppressor of presenilin protein 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020993.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17582

Conserved Domains (1) summary

sd00017
Location:114 → 134

ZF_C2H2; C2H2 Zn finger [structural motif]