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    glt-5 Amino acid transporter [ Caenorhabditis elegans ]

    Gene ID: 174530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glt-5
    Official Full Name
    Amino acid transporter
    Primary source
    WormBase:WBGene00001623
    Locus tag
    CELE_Y53C12A.2
    See related
    AllianceGenome:WB:WBGene00001623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in pharynx. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glt-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (9706481..9708885, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene tRNA-uridine aminocarboxypropyltransferase 1 Neighboring gene Protein YIPF Neighboring gene ncRNA Neighboring gene tRNA-Phe Neighboring gene Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity. Shioda T, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37722055, Free PMC Article
    2. Caenorhabditis elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity. Mano I, et al. J Neurochem, 2009 Mar. PMID 19054279
    3. Caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse. Mano I, et al. J Biol Chem, 2007 Nov 23. PMID 17681948
    4. Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans. Wang L, et al. iScience, 2022 Dec 22. PMID 36567707, Free PMC Article
    5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutral amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Amino acid transporter
    NP_496094.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9706481..9708885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063693.5 → NP_496094.1  Amino acid transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496094.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18210
      Conserved Domains (1) summary
      pfam00375
      Location:21 → 442
      SDF; Sodium:dicarboxylate symporter family
    Nucleotide Protein
    Heading Accession and Version

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