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    prk-2 Serine/threonine-protein kinase prk-2 [ Caenorhabditis elegans ]

    Gene ID: 175437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prk-2
    Official Full Name
    Serine/threonine-protein kinase prk-2
    Primary source
    WormBase:WBGene00004183
    Locus tag
    CELE_F45H7.4
    See related
    AllianceGenome:WB:WBGene00004183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in regulation of synapse assembly. Predicted to be active in cytoplasm. Orthologous to several human genes including PIM1 (Pim-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prk-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (3363668..3366808, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene START domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PIM-Related Kinases Selectively Regulate Olfactory Sensations in Caenorhabditis elegans. Kalichamy KS, et al. eNeuro, 2019 Jul/Aug. PMID 31387876, Free PMC Article
    2. Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10. Zheng Q, et al. Development, 2011 Jan. PMID 21115607, Free PMC Article
    3. Transposon Tc1-derived, sequence-tagged sites in Caenorhabditis elegans as markers for gene mapping. Korswagen HC, et al. Proc Natl Acad Sci U S A, 1996 Dec 10. PMID 8962114, Free PMC Article
    4. Reverse genetics by chemical mutagenesis in Caenorhabditis elegans. Jansen G, et al. Nat Genet, 1997 Sep. PMID 9288111
    5. Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank. Zwaal RR, et al. Proc Natl Acad Sci U S A, 1993 Aug 15. PMID 8395047, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase prk-2
    NP_497696.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3363668..3366808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065295.8 → NP_497696.2  Serine/threonine-protein kinase prk-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497696.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20443
      Conserved Domains (2) summary
      cd14005
      Location:30 → 285
      STKc_PIM; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase
      pfam00069
      Location:31 → 285
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20443.2

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