chs-1 Chitin synthase chs-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: chs-1
Official Full Name: Chitin synthase chs-1
Primary source: WormBase:WBGene00000496
Locus tag: CELE_T25G3.2
See related: AllianceGenome:WB:WBGene00000496
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chitin synthase activity. Involved in chitin biosynthetic process; eggshell formation; and positive regulation of protein localization to cell cortex. Located in cell cortex and plasma membrane. Is expressed in Psub1. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See chs-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (7554855..7559629)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The chitin synthase gene chs-1 is essential for C. elegans development and responsible for chitin deposition in the eggshell.
Title: The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25G3.2 (e-PCR)
- UniSTS:308118

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chitin synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chitin synthase activity	IEA Inferred from Electronic Annotation more info
enables chitin synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chitin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Chitin synthase chs-1

NP_492113.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7554855..7559629

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059712.6 → NP_492113.2 Chitin synthase chs-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492113.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECD6

Conserved Domains (2) summary

cd04190
Location:492 → 810

Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin

COG1215
Location:647 → 982

BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]