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    nkb-2 Sodium/potassium-transporting ATPase subunit beta [ Caenorhabditis elegans ]

    Gene ID: 177950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nkb-2
    Official Full Name
    Sodium/potassium-transporting ATPase subunit beta
    Primary source
    WormBase:WBGene00008074
    Locus tag
    CELE_C43F9.6
    See related
    AllianceGenome:WB:WBGene00008074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; essential hypertension; and stomach cancer. Orthologous to several human genes including ATP4B (ATPase H+/K+ transporting subunit beta); ATP1B4 (ATPase Na+/K+ transporting family member beta 4); and ATP1B1 (ATPase Na+/K+ transporting subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nkb-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (10590925..10593042)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Acyl_transf_3 domain-containing protein Neighboring gene Transmembrane protein Neighboring gene EGF-like domain-containing protein Neighboring gene Neuropeptide-Like Protein Neighboring gene DUF148 domain-containing protein;Neuropeptide-Like Protein Neighboring gene Methyltransferase FkbM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sodium:potassium-exchanging ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/potassium-transporting ATPase subunit beta
    NP_501958.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10590925..10593042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069557.4 → NP_501958.1  Sodium/potassium-transporting ATPase subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUG9
      Conserved Domains (1) summary
      cl08255
      Location:102 → 340
      Na_K-ATPase; Sodium / potassium ATPase beta chain
    Nucleotide Protein
    Heading Accession and Version

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