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    sng-1 Synaptogyrin homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 180995, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sng-1
    Official Full Name
    Synaptogyrin homolog 1
    Primary source
    WormBase:WBGene00004912
    Locus tag
    CELE_T08A9.3
    See related
    AllianceGenome:WB:WBGene00004912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in regulation of exocytosis and synaptic vesicle transport. Located in synaptic vesicle. Is expressed in muscle cell and nervous system. Orthologous to several human genes including SYNGR1 (synaptogyrin 1); SYNGR2 (synaptogyrin 2); and SYNGR4 (synaptogyrin 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sng-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (7327601..7329705)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein Neighboring gene TransThyretin-Related family domain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved mechanism of synaptogyrin localization. Zhao H, et al. Mol Biol Cell, 2001 Aug. PMID 11514616, Free PMC Article
    2. Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans. Abraham C, et al. Proc Natl Acad Sci U S A, 2006 May 23. PMID 16698939, Free PMC Article
    3. Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans. Abraham C, et al. Neuroscience, 2011 Sep 8. PMID 21689733
    4. The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission in Caenorhabditis elegans. Pannone L, et al. Front Mol Neurosci, 2023. PMID 37324589, Free PMC Article
    5. Sensory transduction channel subunits, tax-4 and tax-2, modify presynaptic molecular architecture in C. elegans. Hellman AB, et al. PLoS One, 2011. PMID 21915351, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these observations assign a distinct modulatory and redundant neuronal function to synaptogyrin.
      Title: Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in regulation of exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Synaptogyrin homolog 1
    NP_509239.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7327601..7329705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076838.6 → NP_509239.1  Synaptogyrin homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76735, Q22340
      Conserved Domains (1) summary
      pfam01284
      Location:21 → 169
      MARVEL; Membrane-associating domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76735.1

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