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    acdh-2 Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein;Acyl-CoA_dh_N domain-containing protein;Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 173940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acdh-2
    Official Full Name
    Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein;Acyl-CoA_dh_N domain-containing protein;Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
    Primary source
    WormBase:WBGene00015894
    Locus tag
    CELE_C17C3.12
    See related
    AllianceGenome:WB:WBGene00015894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acyl-CoA dehydrogenase activity. Predicted to be active in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and muscle cell. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acdh-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (5544778..5547492, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene INSulin related Neighboring gene F-box domain-containing protein Neighboring gene DUF38 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans. Hall RA, et al. Mol Biochem Parasitol, 2008 Oct. PMID 18640159
    2. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Heimbucher T, et al. Nat Commun, 2020 Oct 2. PMID 33009389, Free PMC Article
    3. A metabolic regulatory network for the Caenorhabditis elegans intestine. Bhattacharya S, et al. iScience, 2022 Aug 19. PMID 35847555, Free PMC Article
    4. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article
    5. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein;Acyl-CoA_dh_N domain-containing protein;Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
    NP_001343623.1
    • Confirmed by transcript evidence
    NP_001360428.1
    • Confirmed by transcript evidence
    NP_001379683.1
    • Confirmed by transcript evidence
    NP_001380222.1
    • Confirmed by transcript evidence
    NP_495066.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5544778..5547492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393073.1 → NP_001379683.1  Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BIB0
      Conserved Domains (1) summary
      cl09933
      Location:38 → 90
      ACAD; Acyl-CoA dehydrogenase

    2. NM_001393074.1 → NP_001380222.1  Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C369
      Conserved Domains (1) summary
      pfam02771
      Location:37 → 133
      Acyl-CoA_dh_N; Acyl-CoA dehydrogenase, N-terminal domain

    3. NM_001373716.3 → NP_001360428.1  Acyl-CoA_dh_N domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2X1
      Conserved Domains (1) summary
      cl09933
      Location:38 → 261
      ACAD; Acyl-CoA dehydrogenase

    4. NM_001356838.3 → NP_001343623.1  Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYU0
      Conserved Domains (1) summary
      cl09933
      Location:38 → 379
      ACAD; Acyl-CoA dehydrogenase

    5. NM_062665.9 → NP_495066.2  Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495066.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYT9
      Conserved Domains (2) summary
      COG1960
      Location:36 → 308
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
      cl09933
      Location:38 → 308
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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