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    pct-1 Cyclin-dependent kinase 17 [ Caenorhabditis elegans ]

    Gene ID: 177615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pct-1
    Official Full Name
    Cyclin-dependent kinase 17
    Primary source
    WormBase:WBGene00003961
    Locus tag
    CELE_C07G1.3
    See related
    AllianceGenome:WB:WBGene00003961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Located in axon and dendrite. Orthologous to several human genes including CDK16 (cyclin dependent kinase 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pct-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (8176482..8188882)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CRIB domain-containing protein Neighboring gene ncRNA Neighboring gene Glutaredoxin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Axonal transport: CDKs as traffic signals for motor-ists along the axon? Holzbaur E. Curr Biol, 2010 Aug 10. PMID 20692613
    2. Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Ou CY, et al. Cell, 2010 May 28. PMID 20510931, Free PMC Article
    3. Ubiquitin ligase activity inhibits Cdk5 to control axon termination. Desbois M, et al. PLoS Genet, 2022 Apr. PMID 35421092, Free PMC Article
    4. Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway. Wong C, et al. PLoS Genet, 2023 Apr. PMID 37058536, Free PMC Article
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-dependent kinase 17
    NP_001379548.1
    • Confirmed by transcript evidence
    NP_501372.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8176482..8188882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068971.8 → NP_501372.1  Cyclin-dependent kinase 17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501372.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I7M8
      Conserved Domains (2) summary
      PLN00009
      Location:235 → 524
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07844
      Location:237 → 519
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    2. NM_001392344.1 → NP_001379548.1  Cyclin-dependent kinase 17 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDS3, Q8I7M8
      Conserved Domains (1) summary
      cd07844
      Location:327 → 609
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    RNA

    1. NR_131581.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I7M8.1

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