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    mlt-2 ANK_REP_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlt-2
    Official Full Name
    ANK_REP_REGION domain-containing protein
    Primary source
    WormBase:WBGene00007252
    Locus tag
    CELE_C01H6.2
    See related
    AllianceGenome:WB:WBGene00007252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in ecdysis, collagen and cuticulin-based cuticle. Predicted to be active in cilium. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlt-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (7204541..7207717, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Flavin-containing monooxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans. Lažetić V, et al. Genetics, 2017 Jan. PMID 27799278, Free PMC Article
    2. Titanium Dioxide (TiO(2)) Nanoparticle Toxicity in a Caenorhabditis elegans Model. Huang ST, et al. Toxics, 2023 Dec 5. PMID 38133390, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in ecdysis, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ANK_REP_REGION domain-containing protein
    NP_492036.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7204541..7207717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059635.4 → NP_492036.2  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492036.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17583
      Conserved Domains (4) summary
      PHA02876
      Location:9 → 214
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:201 → 351
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:51 → 79
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:53 → 135
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version

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