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    fubl-4 K Homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187350, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fubl-4
    Official Full Name
    K Homology domain-containing protein
    Primary source
    WormBase:WBGene00019692
    Locus tag
    CELE_M01A10.1
    See related
    AllianceGenome:WB:WBGene00019692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA processing and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KHSRP (KH-type splicing regulatory protein); FUBP1 (far upstream element binding protein 1); and FUBP3 (far upstream element binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fubl-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (5563827..5566269)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Lethal giant larvae homologue 2 domain-containing protein;V-SNARE coiled-coil homology domain-containing protein Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 Neighboring gene ncRNA Neighboring gene DUF1080 domain-containing protein Neighboring gene CSD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    K Homology domain-containing protein
    NP_491627.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5563827..5566269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059226.7 → NP_491627.2  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491627.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91393
      Conserved Domains (4) summary
      smart00322
      Location:147 → 217
      KH; K homology RNA-binding domain
      cd00105
      Location:238 → 302
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:321 → 381
      KH_1; KH domain
      pfam09005
      Location:537 → 572
      DUF1897; Domain of unknown function (DUF1897)
    Nucleotide Protein
    Heading Accession and Version

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