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    tiar-1 Cytotoxic granule-associated RNA binding protein tiar-1;RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tiar-1
    Official Full Name
    Cytotoxic granule-associated RNA binding protein tiar-1;RRM domain-containing protein
    Primary source
    WormBase:WBGene00015943
    Locus tag
    CELE_C18A3.5
    See related
    AllianceGenome:WB:WBGene00015943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in several processes, including determination of adult lifespan; nematode larval development; and response to UV. Located in P granule; cytoplasmic stress granule; and nucleus. Is expressed in several structures, including germ line; hypodermis; intestine; nervous system; and somatic cell. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein) and TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tiar-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (5712338..5714823, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Organic solute transporter alpha-like protein 2 Neighboring gene Uncharacterized protein Neighboring gene Late ELOngation arrest Neighboring gene putative rRNA-processing protein EBP2 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans. Huelgas-Morales G, et al. G3 (Bethesda), 2016 Apr 7. PMID 26865701, Free PMC Article
    2. Two predicted α-helices within the prion-like domain of TIAR-1 play a crucial role in its association with stress granules in Caenorhabditis elegans. Fuentes-Jiménez DA, et al. Front Cell Dev Biol, 2023. PMID 38161334, Free PMC Article
    3. Phosphofructokinase relocalizes into subcellular compartments with liquid-like properties in vivo. Jang S, et al. Biophys J, 2021 Apr 6. PMID 32853565, Free PMC Article
    4. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Silva-García CG, et al. Genesis, 2013 Oct. PMID 23913578
    5. Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening in C. elegans. Dhananjay S, et al. MicroPubl Biol, 2022. PMID 36530473, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cytotoxic granule-associated RNA binding protein tiar-1;RRM domain-containing protein
    NP_001359874.1
    • Partially confirmed by transcript evidence
    NP_495120.1
    • Confirmed by transcript evidence
    NP_495121.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5712338..5714823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373724.2 → NP_001359874.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QV6
      Conserved Domains (2) summary
      COG0724
      Location:2 → 80
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:48 → 81
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_062720.4 → NP_495121.1  Cytotoxic granule-associated RNA binding protein tiar-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495121.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95QV8
      Conserved Domains (1) summary
      TIGR01628
      Location:47 → 302
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    3. NM_062719.8 → NP_495120.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QV7
      Conserved Domains (2) summary
      cd12354
      Location:209 → 279
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
      cl17169
      Location:104 → 178
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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