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    vps-26 Vacuolar protein sorting-associated protein 26 [ Caenorhabditis elegans ]

    Gene ID: 177764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-26
    Official Full Name
    Vacuolar protein sorting-associated protein 26
    Primary source
    WormBase:WBGene00006931
    Locus tag
    CELE_T20D3.7
    See related
    AllianceGenome:WB:WBGene00006931
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Located in cytosol. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to several human genes including VPS26B (VPS26 retromer complex component B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-26 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (9339400..9341790, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Solute carrier family 25 member 51 Neighboring gene HIG1 domain-containing protein Neighboring gene Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Neighboring gene Piezo-type mechanosensitive ion channel component 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The retromer complex regulates C. elegans development and mammalian ciliogenesis. Xie S, et al. J Cell Sci, 2022 May 15. PMID 35510502, Free PMC Article
    2. The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling. Zhang Q, et al. Cell, 2018 Aug 9. PMID 30057120, Free PMC Article
    3. Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Lu N, et al. Mol Biol Cell, 2011 Feb 1. PMID 21148288, Free PMC Article
    4. Wnt gradient formation requires retromer function in Wnt-producing cells. Coudreuse DY, et al. Science, 2006 May 12. PMID 16645052
    5. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. Kanamori T, et al. EMBO J, 2008 Jun 18. PMID 18497747, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Vacuolar protein sorting-associated protein 26
    NP_001129871.1
    • Confirmed by transcript evidence
    NP_001263763.1
    • Confirmed by transcript evidence
    NP_001380127.1
    • Confirmed by transcript evidence
    NP_501644.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9339400..9341790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069243.5 → NP_501644.1  Vacuolar protein sorting-associated protein 26 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01258
      Conserved Domains (1) summary
      pfam03643
      Location:59 → 334
      Vps26; Vacuolar protein sorting-associated protein 26

    2. NM_001276834.3 → NP_001263763.1  Vacuolar protein sorting-associated protein 26 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E917
      Conserved Domains (1) summary
      pfam03643
      Location:59 → 336
      Vps26; Vacuolar protein sorting-associated protein 26

    3. NM_001136399.3 → NP_001129871.1  Vacuolar protein sorting-associated protein 26 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01258
      UniProtKB/TrEMBL
      B3GWB9
      Conserved Domains (1) summary
      pfam03643
      Location:7 → 282
      Vps26; Vacuolar protein sorting-associated protein 26

    4. NM_001392366.1 → NP_001380127.1  Vacuolar protein sorting-associated protein 26 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E6W6
      Conserved Domains (1) summary
      pfam03643
      Location:7 → 284
      Vps26; Vacuolar protein sorting-associated protein 26
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01258.2

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