ets-5 ETS domain-containing protein;ETS domain-containing transcription factor ets-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ets-5
Official Full Name: ETS domain-containing protein;ETS domain-containing transcription factor ets-5
Primary source: WormBase:WBGene00016600
Locus tag: CELE_C42D8.4
See related: AllianceGenome:WB:WBGene00016600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in nervous system. Orthologous to human FEV (FEV transcription factor, ETS family member). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ets-5 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (5079657..5084526, complement)

Chromosome X - NC_003284.9

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons
Title: A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS6-137 (e-PCR)
- UniSTS:242516

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ETS domain-containing protein;ETS domain-containing transcription factor ets-5

NP_001263956.1

Confirmed by transcript evidence

NP_001370489.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5079657..5084526 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383573.1 → NP_001370489.1 ETS domain-containing transcription factor ets-5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18579

Conserved Domains (1) summary

smart00413
Location:34 → 119

ETS; erythroblast transformation specific domain
NM_001277027.4 → NP_001263956.1 ETS domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263956.1

Status: REVIEWED

UniProtKB/TrEMBL

I7KSB9

Conserved Domains (1) summary

smart00413
Location:72 → 157

ETS; erythroblast transformation specific domain