U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    haf-9 ABC-type antigen peptide transporter [ Caenorhabditis elegans ]

    Gene ID: 172288, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    haf-9
    Official Full Name
    ABC-type antigen peptide transporter
    Primary source
    WormBase:WBGene00001819
    Locus tag
    CELE_ZK484.2
    See related
    AllianceGenome:WB:WBGene00001819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in lysosomal transport and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in lysosomal membrane. Is expressed in intestine and rectal gland cell. Orthologous to human ABCB9 (ATP binding cassette subfamily B member 9). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See haf-9 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (6081812..6085957)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Histone H1 Neighboring gene Treslin STD domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MS Related Protein Neighboring gene Phosphoglycerate mutase family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. ABC transporters and RNAi in Caenorhabditis elegans. Timmons LD. J Bioenerg Biomembr, 2007 Dec. PMID 17994271
    2. Molecular dissection of Caenorhabditis elegans ATP-binding cassette transporter protein HAF-4 to investigate its subcellular localization and dimerization. Tanji T, et al. Biochem Biophys Res Commun, 2017 Aug 19. PMID 28427936
    3. Co-operative function and mutual stabilization of the half ATP-binding cassette transporters HAF-4 and HAF-9 in Caenorhabditis elegans. Tanji T, et al. Biochem J, 2013 Jun 15. PMID 23458156
    4. Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like. Kawai H, et al. Mol Biol Cell, 2009 Jun. PMID 19403699, Free PMC Article
    5. CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans. Vatamaniuk OK, et al. J Biol Chem, 2005 Jun 24. PMID 15840570

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HAF-4- and HAF-9-localizing organelles are distinct intestinal organelles associated with the endocytic pathway.
      Title: Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells.
    2. HAF-4 and HAF-9 form a heterodimer; knockdown experiments suggest that HAF-4-HAF-9 heterodimer formation is required for their stabilization.
      Title: Co-operative function and mutual stabilization of the half ATP-binding cassette transporters HAF-4 and HAF-9 in Caenorhabditis elegans.
    3. These results demonstrate that two ABC transporters, HAF-4 and HAF-9, are related to intestinal granular formation and some other physiological aspects.
      Title: Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ABC-type antigen peptide transporter
    NP_491754.1
    • Confirmed by transcript evidence
    NP_871810.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6081812..6085957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059353.8 → NP_491754.1  ABC-type antigen peptide transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44897
      Conserved Domains (1) summary
      TIGR00958
      Location:19 → 757
      3a01208; Conjugate Transporter-2 (CT2) Family protein

    2. NM_182010.5 → NP_871810.1  ABC-type antigen peptide transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871810.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IA64
      Conserved Domains (1) summary
      TIGR00958
      Location:19 → 664
      3a01208; Conjugate Transporter-2 (CT2) Family protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous