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    guk-1 guanylate kinase [ Caenorhabditis elegans ]

    Gene ID: 171963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    guk-1
    Official Full Name
    guanylate kinase
    Primary source
    WormBase:WBGene00020190
    Locus tag
    CELE_T03F1.8
    See related
    AllianceGenome:WB:WBGene00020190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate kinase activity. Predicted to be involved in GDP metabolic process and GMP metabolic process. Predicted to be active in cytosol. Is expressed in anchor cell. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See guk-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (3859369..3862733, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Dimethyladenosine transferase 1, mitochondrial Neighboring gene HoloCentric chromosome binding Protein Neighboring gene putative phosphoglycerate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanylate kinase
    NP_001122511.1
    • Confirmed by transcript evidence
    NP_491243.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3859369..3862733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058842.7 → NP_491243.1  guanylate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91425
      Conserved Domains (1) summary
      TIGR03263
      Location:25 → 208
      guanyl_kin; guanylate kinase

    2. NM_001129039.6 → NP_001122511.1  guanylate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HU98
      Conserved Domains (1) summary
      TIGR03263
      Location:14 → 197
      guanyl_kin; guanylate kinase
    Nucleotide Protein
    Heading Accession and Version

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