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    dhs-2 17-beta-hydroxysteroid dehydrogenase type 6 [ Caenorhabditis elegans ]

    Gene ID: 172183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-2
    Official Full Name
    17-beta-hydroxysteroid dehydrogenase type 6
    Primary source
    WormBase:WBGene00000966
    Locus tag
    CELE_F55A12.4
    See related
    AllianceGenome:WB:WBGene00000966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Orthologous to several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (5354181..5357029)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Telomere_reg-2 domain-containing protein Neighboring gene RNA cytidine acetyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. D-beta-hydroxybutyrate extends lifespan in C. elegans. Edwards C, et al. Aging (Albany NY), 2014 Aug. PMID 25127866, Free PMC Article
    2. Identification and characterization of differentially expressed genes in Caenorhabditis elegans in response to pathogenic and nonpathogenic Stenotrophomonas maltophilia. Radeke LJ, et al. BMC Microbiol, 2020 Jun 19. PMID 32560629, Free PMC Article
    3. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    17-beta-hydroxysteroid dehydrogenase type 6
    NP_001309486.1
    • Confirmed by transcript evidence
    NP_001379718.1
    • Confirmed by transcript evidence
    NP_491575.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5354181..5357029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059174.9 → NP_491575.1  17-beta-hydroxysteroid dehydrogenase type 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491575.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01758
      Conserved Domains (2) summary
      pfam00106
      Location:70 → 261
      adh_short; short chain dehydrogenase
      cl21454
      Location:70 → 354
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001392303.1 → NP_001379718.1  17-beta-hydroxysteroid dehydrogenase type 6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NJ7
      Conserved Domains (1) summary
      cl21454
      Location:45 → 329
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001322672.3 → NP_001309486.1  17-beta-hydroxysteroid dehydrogenase type 6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYZ9
      Conserved Domains (1) summary
      cl21454
      Location:6 → 162
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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