fkh-9 Forkhead transcription factor fkh-9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fkh-9
Official Full Name: Forkhead transcription factor fkh-9
Primary source: WormBase:WBGene00001441
Locus tag: CELE_K03C7.2
See related: AllianceGenome:WB:WBGene00001441
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including axon regeneration; determination of adult lifespan; and learning or memory. Acts upstream of or within ERAD pathway and defense response to other organism. Located in nucleus. Is expressed in several structures, including hypodermis; intestine; neurons; rectal valve cell; and somatic nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fkh-9 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (3816851..3826963, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Further characterization of FKH-9 suggests that loss of FKH-9 enhances resistance to the ER toxin tunicamycin and results in enhanced ER-associated degradation (ERAD).
Title: Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.
the C. elegans 44 bp enhancer from vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-beta/Sma/Mab pathway
Title: A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway.

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General gene information

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Markers

K03C7.2 (e-PCR)
- UniSTS:320322

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to other organism	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in learning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in short-term memory	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Forkhead transcription factor fkh-9

NP_001024760.1

Confirmed by transcript evidence

NP_001024761.1

Confirmed by transcript evidence

NP_001379922.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3816851..3826963 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029589.4 → NP_001024760.1 Forkhead transcription factor fkh-9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024760.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21187, Q2L6X6, Q7Z136

Conserved Domains (1) summary

smart00339
Location:66 → 153

FH; FORKHEAD
NM_001029590.7 → NP_001024761.1 Forkhead transcription factor fkh-9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024761.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7Z136

Conserved Domains (1) summary

smart00339
Location:46 → 133

FH; FORKHEAD
NM_001392752.1 → NP_001379922.1 Forkhead transcription factor fkh-9 [Caenorhabditis elegans]

Status: REVIEWED