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    ced-11 Protein ced-11 [ Caenorhabditis elegans ]

    Gene ID: 176288, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ced-11
    Official Full Name
    Protein ced-11
    Primary source
    WormBase:WBGene00000425
    Locus tag
    CELE_ZK512.3
    See related
    AllianceGenome:WB:WBGene00000425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monoatomic cation channel activity. Involved in apoptotic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in apoptotic cell; head; hypodermis; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ced-11 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (9119556..9125162)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein transport protein sec-16A.1 Neighboring gene DUF4752 family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans. Driscoll K, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28760991, Free PMC Article
    2. Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi. Verma S, et al. Commun Biol, 2020 Jul 28. PMID 32724078, Free PMC Article
    3. Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3. Shaham S, et al. Genetics, 1999 Dec. PMID 10581274, Free PMC Article
    4. The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Barr MM, et al. Curr Biol, 2001 Sep 4. PMID 11553327
    5. Invertebrate TRP proteins as functional models for mammalian channels. Vriens J, et al. Pflugers Arch, 2004 Dec. PMID 15480752

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein ced-11
    NP_499021.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9119556..9125162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066620.6 → NP_499021.1  Protein ced-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34641
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34641.1

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