arx-2 Actin-related protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: arx-2
Official Full Name: Actin-related protein 2
Primary source: WormBase:WBGene00000200
Locus tag: CELE_K07C5.1
See related: AllianceGenome:WB:WBGene00000200
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; embryonic morphogenesis; and epithelial cell migration. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of Arp2/3 protein complex. Predicted to be active in cell cortex. Is expressed in several structures, including Q cell; anchor cell; epithelial cell; germ line; and head. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See arx-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (10335463..10338355, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arp2/3 is enriched at the cell cortex and is required for stable membrane-cytoskeletal linkages.
Title: In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K07C5.1 (e-PCR)
- UniSTS:311446

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Actin-related protein 2

NP_505657.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10335463..10338355 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073256.8 → NP_505657.1 Actin-related protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505657.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P53489

Conserved Domains (2) summary

smart00268
Location:6 → 392

ACTIN; Actin

cl17037
Location:1 → 383

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily