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    ndg-4 Nose resistant-to-fluoxetine protein N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndg-4
    Official Full Name
    Nose resistant-to-fluoxetine protein N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00003577
    Locus tag
    CELE_F56F3.2
    See related
    AllianceGenome:WB:WBGene00003577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Is expressed in hypodermal cell and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ndg-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (4462833..4467377, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin-like domain-containing protein Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. How do antidepressants work? Prospects for genetic analysis of drug mechanisms. Schafer WR. Cell, 1999 Sep 3. PMID 10490094
    2. Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans. Brejning J, et al. Aging Cell, 2014 Feb. PMID 24286221, Free PMC Article
    3. Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins. Choy RK, et al. Mol Cell, 1999 Aug. PMID 10488330
    4. Dietary manipulation implicates lipid signaling in the regulation of germ cell maintenance in C. elegans. Watts JL, et al. Dev Biol, 2006 Apr 15. PMID 16487504, Free PMC Article
    5. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Lehner B, et al. Nat Genet, 2006 Aug. PMID 16845399

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation of the NDG-4 protein results in increased organismal stress resistance and lifespan.
      Title: Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans.
    2. Ndg-4 functions in the intestine are required for the function of Nrf-5
      Title: Fluoxetine-resistance genes in Caenorhabditis elegans function in the intestine and may act in drug transport.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nose resistant-to-fluoxetine protein N-terminal domain-containing protein
    NP_001022618.1
    • Confirmed by transcript evidence
    NP_001022619.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4462833..4467377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027448.4 → NP_001022619.1  Nose resistant-to-fluoxetine protein N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MD1
      Conserved Domains (2) summary
      smart00703
      Location:110 → 215
      NRF; N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4)
      COG1835
      Location:325 → 666
      OafA; Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis]

    2. NM_001027447.7 → NP_001022618.1  Nose resistant-to-fluoxetine protein N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF61
      Conserved Domains (2) summary
      smart00703
      Location:110 → 215
      NRF; N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4)
      COG1835
      Location:325 → 668
      OafA; Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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