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    rpn-13 Proteasomal ubiquitin receptor ADRM1;Proteasomal ubiquitin receptor ADRM1 homolog [ Caenorhabditis elegans ]

    Gene ID: 3565888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpn-13
    Official Full Name
    Proteasomal ubiquitin receptor ADRM1;Proteasomal ubiquitin receptor ADRM1 homolog
    Primary source
    WormBase:WBGene00016981
    Locus tag
    CELE_C56G2.7
    See related
    AllianceGenome:WB:WBGene00016981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin-specific protease binding activity. Predicted to be involved in proteasome assembly. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, lid subcomplex. Is expressed in intestine; neurons; and seam cell. Orthologous to human ADRM1 (ADRM1 26S proteasome ubiquitin receptor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rpn-13 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (6340113..6341928, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Very-long-chain 3-oxooacyl-coA reductase let-767 Neighboring gene DUF4604 domain-containing protein Neighboring gene tRNA MethylTransferase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Matilainen O, et al. Cell Rep, 2013 Jun 27. PMID 23770237
    2. The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans. Lee H, et al. Genetics, 2019 Oct. PMID 31358532, Free PMC Article
    3. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Lin XX, et al. Nat Commun, 2018 Oct 23. PMID 30353013, Free PMC Article
    4. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables endopeptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Proteasomal ubiquitin receptor ADRM1;Proteasomal ubiquitin receptor ADRM1 homolog
    NP_001348746.1
    • Confirmed by transcript evidence
    NP_498387.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6340113..6341928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361721.4 → NP_001348746.1  Proteasomal ubiquitin receptor ADRM1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5ATW5
      Conserved Domains (2) summary
      cd13314
      Location:19 → 128
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:243 → 333
      RPN13_C; UCH-binding domain

    2. NM_065986.10 → NP_498387.2  Proteasomal ubiquitin receptor ADRM1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498387.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09289
      Conserved Domains (2) summary
      cd13314
      Location:19 → 128
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:237 → 336
      RPN13_C; UCH-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09289.2

    Gene LinkOut

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