bbs-8 Tetratricopeptide repeat protein 8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bbs-8
Official Full Name: Tetratricopeptide repeat protein 8
Primary source: WormBase:WBGene00000244
Locus tag: CELE_T25F10.5
See related: AllianceGenome:WB:WBGene00000244
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including cilium organization; olfactory learning; and positive regulation of intracellular transport. Located in several cellular components, including ciliary basal body; ciliary base; and dendrite terminus. Is expressed in head and nervous system. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bbs-8 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (6762467..6765072, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutations in the Caenorhabditis elegans bbs-8 gene cause structural and functional defects in cilia
Title: Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25F10.5 (e-PCR)
- UniSTS:311003

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intraciliary anterograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intraciliary retrograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to ciliary membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to microvillus membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of BBSome	IBA Inferred from Biological aspect of Ancestor more info
part_of BBSome	IEA Inferred from Electronic Annotation more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary base	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite terminus	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tetratricopeptide repeat protein 8

NP_504711.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6762467..6765072 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072310.7 → NP_504711.2 Tetratricopeptide repeat protein 8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504711.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23049

Conserved Domains (2) summary

COG0457
Location:215 → 483

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:388 → 416

TPR; TPR repeat [structural motif]