mtm-3 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mtm-3
Official Full Name: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3
Primary source: WormBase:WBGene00003476
Locus tag: CELE_T24A11.1
See related: AllianceGenome:WB:WBGene00003476
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables inositol bisphosphate phosphatase activity and phosphatidylinositol phosphate phosphatase activity. Involved in several processes, including determination of adult lifespan; positive regulation of autophagosome maturation; and regulation of endocytosis. Located in cytoplasm. Is expressed in body wall musculature and head neurons. Orthologous to several human genes including MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mtm-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (3789982..3800467, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MTM-3 is recruited to autophagosomes by PtdIns3P, and loss of MTM-3 causes increased autophagic association of ATG-18 in a PtdIns3P-dependent manner.
Title: PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
A role of ceMTM3 is in regulating autophagy and maintaining muscle fibers.
Title: Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans.
This study thus reveals an important role of the MTM phosphatases in maintaining muscle function.
Title: Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T24A11.1 (e-PCR)
- UniSTS:315084

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol bisphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol trisphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

NP_001022794.2

Partially confirmed by transcript evidence

NP_497766.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3789982..3800467 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027623.7 → NP_001022794.2 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022794.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A8NBE6, Q22712, Q9U360, Q9XTK4

Conserved Domains (2) summary

smart00064
Location:814 → 883

FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1

pfam06602
Location:258 → 574

Myotub-related; Myotubularin-like phosphatase domain
NM_065365.10 → NP_497766.3 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497766.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22712

Conserved Domains (2) summary

smart00064
Location:810 → 879

FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1

pfam06602
Location:254 → 570

Myotub-related; Myotubularin-like phosphatase domain