dcs-1 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dcs-1
Official Full Name: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase
Primary source: WormBase:WBGene00000940
Locus tag: CELE_Y113G7A.9
See related: AllianceGenome:WB:WBGene00000940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA 7-methylguanosine cap binding activity; hydrolase activity, acting on acid anhydrides; and sulfate adenylyltransferase (ADP) activity. Involved in several processes, including mRNA metabolic process; purine ribonucleotide metabolic process; and response to heat. Located in cytoplasm and nucleus. Orthologous to human DCPS (decapping enzyme, scavenger). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dcs-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (20087848..20090743, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DCS-1 is part of a degradation complex that performs microRNA turnover in animals.
Title: The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans.
The rate dynamics of DcpS on its natural substrates and dinucleotide cap analogs, modified in the nucleoside base or ribose moiety, was examined.
Title: Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies.
dual catalytic activity of DspS as a hydrolase and a phosphorylase was discovered.
Title: Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP).
DcpS (scavenger decapping enzyme) from nematode C. elegans readily hydrolyzes both monomethyl- and trimethylguanosine cap analogues.
Title: Kinetics of C. elegans DcpS cap hydrolysis studied by fluorescence spectroscopy.
dsc-1 encodes a Q50 Paired (Prd)-like homeodomain protein which affects the periodicity of defecation, revealing an unanticipated role for the enteric muscles in regulating this ultradian rhythm.
Title: Specification of muscle neurotransmitter sensitivity by a Paired-like homeodomain protein in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y113G7A.9 (e-PCR)
- UniSTS:321790

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylylsulfatase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables sulfate adenylyltransferase (ADP) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA methylguanosine-cap decapping	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA methylguanosine-cap decapping	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TAS Traceable Author Statement more info	PubMed
involved_in purine ribonucleotide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfur compound metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase

NP_001256897.1

Confirmed by transcript evidence

NP_001364670.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

20087848..20090743 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269968.2 → NP_001256897.1 m7GpppX diphosphatase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256897.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFS4

Conserved Domains (2) summary

pfam05652
Location:27 → 117

DcpS; Scavenger mRNA decapping enzyme (DcpS) N-terminal

pfam11969
Location:149 → 256

DcpS_C; Scavenger mRNA decapping enzyme C-term binding
NM_001377611.2 → NP_001364670.1 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

D8FRQ0

Conserved Domains (1) summary

COG5075
Location:2 → 80

COG5075; Uncharacterized conserved protein [Function unknown]