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    lys-8 LYSozyme [ Caenorhabditis elegans ]

    Gene ID: 173944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lys-8
    Official Full Name
    LYSozyme
    Primary source
    WormBase:WBGene00003097
    Locus tag
    CELE_C17G10.5
    See related
    AllianceGenome:WB:WBGene00003097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in nematode pharyngeal gland morphogenesis. Is expressed in intestine; neurons; and pharyngeal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lys-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (5586178..5587651)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene THAP-type domain-containing protein Neighboring gene Tyrosine-protein phosphatase cdc-14 Neighboring gene Cns1/TTC4 wheel domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Indole produced during dysbiosis mediates host-microorganism chemical communication. Yang RQ, et al. Elife, 2023 Nov 21. PMID 37987602, Free PMC Article
    2. Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals. Zhang L, et al. Arch Pharm Res, 2023 Jul. PMID 37535304
    3. GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans. Hahm JH, et al. Aging Cell, 2011 Apr. PMID 21108728
    4. Antimicrobial proteins in the response to graphene oxide in Caenorhabditis elegans. Ren M, et al. Nanotoxicology, 2017 May. PMID 28490217
    5. Biosafety assessment of Acinetobacter strains isolated from the Three Gorges Reservoir region in nematode Caenorhabditis elegans. Deng Y, et al. Sci Rep, 2021 Oct 5. PMID 34611259, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode pharyngeal gland morphogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LYSozyme
    NP_495083.1
    • Product from WormBase gene class lys;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5586178..5587651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062682.6 → NP_495083.1  LYSozyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09975
      Conserved Domains (1) summary
      cd06416
      Location:56 → 258
      GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
    Nucleotide Protein
    Heading Accession and Version

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