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    rml-4 NAD(P)-bd_dom domain-containing protein;NAD(P)-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rml-4
    Official Full Name
    NAD(P)-bd_dom domain-containing protein;NAD(P)-binding domain-containing protein
    Primary source
    WormBase:WBGene00015298
    Locus tag
    CELE_C01F1.3
    See related
    AllianceGenome:WB:WBGene00015298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dTDP-glucose 4,6-dehydratase activity. Is expressed in hypodermal cell. Human ortholog(s) of this gene implicated in Catel Manzke syndrome. Orthologous to human TGDS (TDP-glucose 4,6-dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rml-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (4295101..4298950)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Peptidase M12A domain-containing protein Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene Transcription initiation factor IIF subunit alpha Neighboring gene protein-disulfide reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acquired stress resilience through bacteria-to-nematode interdomain horizontal gene transfer. Pandey T, et al. EMBO J, 2023 Dec 11. PMID 37953666, Free PMC Article
    2. Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. O'Rourke D, et al. G3 (Bethesda), 2023 May 2. PMID 36911920, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dTDP-glucose 4,6-dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)-bd_dom domain-containing protein;NAD(P)-binding domain-containing protein
    NP_001040727.1
    • Confirmed by transcript evidence
    NP_001040728.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4295101..4298950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047262.6 → NP_001040727.1  NAD(P)-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040727.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17556
      Conserved Domains (1) summary
      PLN02260
      Location:3 → 625
      PLN02260; probable rhamnose biosynthetic enzyme

    2. NM_001047263.4 → NP_001040728.1  NAD(P)-bd_dom domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040728.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2L6W1
      Conserved Domains (1) summary
      cl21454
      Location:9 → 148
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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