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    chtl-1 Choline transporter-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 180809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chtl-1
    Official Full Name
    Choline transporter-like protein 1
    Primary source
    WormBase:WBGene00018037
    Locus tag
    CELE_F35C8.7
    See related
    AllianceGenome:WB:WBGene00018037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in germ line. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Orthologous to several human genes including SLC44A2 (solute carrier family 44 member 2 (CTL2 blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chtl-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (5355644..5364322, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Putative syntaxin-3 Neighboring gene Profilin-2 Neighboring gene ncRNA Neighboring gene Cholesterol 25-hydroxylase-like protein Neighboring gene Dual specificity mitogen-activated protein kinase kinase jkk-1 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Choline transport and de novo choline synthesis support acetylcholine biosynthesis in Caenorhabditis elegans cholinergic neurons. Mullen GP, et al. Genetics, 2007 Sep. PMID 17603106, Free PMC Article
    2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Choline transporter-like protein 1
    NP_001367416.1
    • Confirmed by transcript evidence
    NP_001367417.1
    • Confirmed by transcript evidence
    NP_741790.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5355644..5364322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380967.2 → NP_001367417.1  Choline transporter-like protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam04515
      Location:415 → 742
      Choline_transpo; Plasma-membrane choline transporter

    2. NM_001380966.3 → NP_001367416.1  Choline transporter-like protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3WFU3, Q20026, Q8MQ62
      Conserved Domains (1) summary
      pfam04515
      Location:413 → 740
      Choline_transpo; Plasma-membrane choline transporter

    3. NM_171686.7 → NP_741790.2  Choline transporter-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741790.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20026
      Conserved Domains (1) summary
      pfam04515
      Location:372 → 697
      Choline_transpo; Plasma-membrane choline transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20026.1

    Gene LinkOut

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