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    tbc-7 Rab-GAP TBC domain-containing protein;TLDc domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180784, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc-7
    Official Full Name
    Rab-GAP TBC domain-containing protein;TLDc domain-containing protein
    Primary source
    WormBase:WBGene00016292
    Locus tag
    CELE_C31H2.1
    See related
    AllianceGenome:WB:WBGene00016292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in cytoplasmic vesicle; membrane; and synapse. Is expressed in body wall musculature; head; intestine; and neurons. Human ortholog(s) of this gene implicated in DOORS syndrome; epilepsy (multiple); and nonsyndromic deafness (multiple). Orthologous to human TBC1D24 (TBC1 domain family member 24). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbc-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    20
    Sequence:
    Chromosome: X; NC_003284.9 (5134280..5146744)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy. Nehammer C, et al. Elife, 2019 Dec 4. PMID 31799933, Free PMC Article
    2. Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway. Wong C, et al. PLoS Genet, 2023 Apr. PMID 37058536, Free PMC Article
    3. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Samuelson AV, et al. Genes Dev, 2007 Nov 15. PMID 18006689, Free PMC Article
    4. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab-GAP TBC domain-containing protein;TLDc domain-containing protein
    NP_001359912.1
    • Confirmed by transcript evidence
    NP_001360675.1
    • Confirmed by transcript evidence
    NP_741779.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5134280..5146744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373289.3 → NP_001359912.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ54
      Conserved Domains (2) summary
      smart00164
      Location:196 → 409
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00584
      Location:498 → 672
      TLDc; domain in TBC and LysM domain containing proteins

    2. NM_171949.9 → NP_741779.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741779.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQB0
      Conserved Domains (2) summary
      smart00164
      Location:156 → 369
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00584
      Location:458 → 632
      TLDc; domain in TBC and LysM domain containing proteins

    3. NM_001373290.4 → NP_001360675.1  TLDc domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INB7
      Conserved Domains (2) summary
      smart00164
      Location:54 → 267
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00584
      Location:356 → 530
      TLDc; domain in TBC and LysM domain containing proteins
    Nucleotide Protein
    Heading Accession and Version

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