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    cyl-1 Cyclin L homolog cyl-1 [ Caenorhabditis elegans ]

    Gene ID: 179643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyl-1
    Official Full Name
    Cyclin L homolog cyl-1
    Primary source
    WormBase:WBGene00000876
    Locus tag
    CELE_C52E4.6
    See related
    AllianceGenome:WB:WBGene00000876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within nematode male tail tip morphogenesis. Predicted to be active in nucleus. Orthologous to several human genes including CCNL1 (cyclin L1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (11991011..11993723, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Histidine kinase Neighboring gene Essential MCU regulator, mitochondrial Neighboring gene Soluble guanylate cyclase gcy-33;guanylate cyclase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CDK-11-Cyclin L is required for gametogenesis and fertility in C. elegans. Williams CW, et al. Dev Biol, 2018 Sep 1. PMID 29886128, Free PMC Article
    2. The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans. Hajdu-Cronin YM, et al. Genetics, 2004 Dec. PMID 15611166, Free PMC Article
    3. cdc-25.2, a Caenorhabditis elegans ortholog of cdc25, is required for male tail morphogenesis. Oh S, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27923661
    4. Caenorhabditis elegans AF4/FMR2 Family Homolog affl-2 Regulates Heat-Shock-Induced Gene Expression. Walton SJ, et al. Genetics, 2020 Aug. PMID 32518061, Free PMC Article
    5. Discovery of novel alternatively spliced C. elegans transcripts by computational analysis of SAGE data. Ruzanov P, et al. BMC Genomics, 2007 Nov 30. PMID 18053145, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin L homolog cyl-1
    NP_506007.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11991011..11993723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073606.6 → NP_506007.1  Cyclin L homolog cyl-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506007.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBX3
      Conserved Domains (2) summary
      cd20532
      Location:95 → 230
      CYCLIN_CCNL_rpt1; first cyclin box found in cyclin-L (CCNL) family
      cd20533
      Location:235 → 330
      CYCLIN_CCNL_rpt2; second cyclin box found in cyclin-L (CCNL) family

    RNA

    1. NR_001507.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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