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    Tlcd1 TLC domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287472, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tlcd1provided by RGD
    Official Full Name
    TLC domain containing 1provided by RGD
    Primary source
    RGD:1359195
    See related
    EnsemblRapid:ENSRNOG00000071015 AllianceGenome:RGD:1359195
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TLCD1 (TLC domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 124.2), Brain (RPKM 47.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tlcd1 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63572541..63574574)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63074469..63076502)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65439104..65441140)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Tnf receptor associated factor 4 Neighboring gene NIMA-related kinase 8 Neighboring gene small nucleolar RNA, C/D box 42A Neighboring gene ribosomal protein L23A Neighboring gene small nucleolar RNA, C/D box 4A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane lipid distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of membrane lipid distribution ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TLC domain-containing protein 1
    Names
    calfacilitin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013858.1NP_001013880.1  TLC domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_001013880.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085876
      UniProtKB/Swiss-Prot
      Q5U2T1
      UniProtKB/TrEMBL
      A0A8I6A667, A6HH14
      Related
      ENSRNOP00000084592.1, ENSRNOT00000098225.2
      Conserved Domains (1) summary
      smart00724
      Location:41234
      TLC; TRAM, LAG1 and CLN8 homology domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63572541..63574574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767957.3XP_008766179.1  TLC domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008766179.1

      UniProtKB/TrEMBL
      A6HH15
      Conserved Domains (1) summary
      smart00724
      Location:14163
      TLC; TRAM, LAG1 and CLN8 homology domains