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    gtf-2E1 HTH TFE/IIEalpha-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gtf-2E1
    Official Full Name
    HTH TFE/IIEalpha-type domain-containing protein
    Primary source
    WormBase:WBGene00013998
    Locus tag
    CELE_ZK550.4
    See related
    AllianceGenome:WB:WBGene00013998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Involved in transcription initiation at RNA polymerase II promoter. Part of transcription factor TFIIE complex. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gtf-2E1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (17255301..17257562)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Peptidase M3A/M3B catalytic domain-containing protein Neighboring gene ncRNA Neighboring gene phytanoyl-CoA dioxygenase Neighboring gene ncRNA Neighboring gene putative phytanoyl-CoA dioxygenase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation. Yamamoto S, et al. Mol Cell Biol, 2001 Jan. PMID 11113176, Free PMC Article
    2. C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair. Thijssen KL, et al. Commun Biol, 2021 Nov 25. PMID 34824371, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HTH TFE/IIEalpha-type domain-containing protein
    NP_503060.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17255301..17257562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070659.9 → NP_503060.1  HTH TFE/IIEalpha-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG49
      Conserved Domains (2) summary
      smart00531
      Location:41 → 188
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:354 → 426
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
    Nucleotide Protein
    Heading Accession and Version

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