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    noca-2 EF-hand domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    noca-2
    Official Full Name
    EF-hand domain-containing protein
    Primary source
    WormBase:WBGene00011444
    Locus tag
    CELE_T04F8.6
    See related
    AllianceGenome:WB:WBGene00011444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in microtubule anchoring at centrosome. Predicted to be active in centrosome. Is expressed in PVDL; PVDR; head; seam cell; and tail. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein) and NINL (ninein like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See noca-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (11667127..11672309)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sidoreflexin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites. He L, et al. PLoS Biol, 2022 Nov. PMID 36395330, Free PMC Article
    2. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article
    3. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in microtubule anchoring at centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand domain-containing protein
    NP_509950.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11667127..11672309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077549.4 → NP_509950.3  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509950.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22167
      Conserved Domains (1) summary
      TIGR02169
      Location:258 → 437
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein
    Heading Accession and Version

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