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    prmt-9 PRotein arginine MethylTransferase [ Caenorhabditis elegans ]

    Gene ID: 178221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prmt-9
    Official Full Name
    PRotein arginine MethylTransferase
    Primary source
    WormBase:WBGene00011939
    Locus tag
    CELE_T23B5.1
    See related
    AllianceGenome:WB:WBGene00011939
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone methyltransferase activity and protein-arginine N-methyltransferase activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Orthologous to human PRMT9 (protein arginine methyltransferase 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prmt-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (12677398..12684378, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene WD repeat and FYVE domain-containing protein 3 Neighboring gene ncRNA Neighboring gene Prokaryotic-type class I peptide chain release factors domain-containing protein Neighboring gene Transcriptional regulator Neighboring gene C3H1-type domain-containing protein;Coiled-coil domain-containing protein Neighboring gene ncRNA Neighboring gene NAD-dependent epimerase/dehydratase domain-containing protein Neighboring gene Integrase catalytic domain-containing protein;RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans PRMT-7 and PRMT-9 Are Evolutionarily Conserved Protein Arginine Methyltransferases with Distinct Substrate Specificities. Hadjikyriacou A, et al. Biochemistry, 2017 May 23. PMID 28441492, Free PMC Article
    2. The C. elegans PRMT-3 possesses a type III protein arginine methyltransferase activity. Takahashi Y, et al. J Recept Signal Transduct Res, 2011 Apr. PMID 21385054
    3. PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins. Hsieh HC, et al. Autophagy, 2024 Jun. PMID 38261662, Free PMC Article
    4. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Wang S, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33046905
    5. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C. elegans PRMT-9 produces symmetric dimethylarginine and MMA on SFTB-2, the conserved C. elegans ortholog of human RNA splicing factor SF3B2, indicating a possible role in the regulation of nematode splicing
      Title: Caenorhabditis elegans PRMT-7 and PRMT-9 Are Evolutionarily Conserved Protein Arginine Methyltransferases with Distinct Substrate Specificities.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-arginine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PRotein arginine MethylTransferase
    NP_001040990.1
    • Product from WormBase gene class prmt;
      Confirmed by transcript evidence
    NP_001040991.1
    • Product from WormBase gene class prmt;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12677398..12684378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047525.5 → NP_001040990.1  PRotein arginine MethylTransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02325
      Conserved Domains (2) summary
      pfam05185
      Location:153 → 421
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17173
      Location:139 → 273
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001047526.3 → NP_001040991.1  PRotein arginine MethylTransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040991.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2EEM4
    Nucleotide Protein
    Heading Accession and Version

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