U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sik2 salt-inducible kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315649, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sik2provided by RGD
    Official Full Name
    salt-inducible kinase 2provided by RGD
    Primary source
    RGD:1559698
    See related
    EnsemblRapid:ENSRNOG00000043498 AllianceGenome:RGD:1559698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Snf1lk2; RGD1559698
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including protein autophosphorylation; regulation of insulin receptor signaling pathway; and regulation of primary metabolic process. Predicted to act upstream of or within insulin receptor signaling pathway and protein phosphorylation. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 133.9), Kidney (RPKM 128.4) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sik2 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60121913..60221707, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51225543..51325343, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55309005..55408608, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ALG9, alpha-1,2-mannosyltransferase Neighboring gene uncharacterized LOC134480165 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene protein phosphatase 2 scaffold subunit A beta Neighboring gene transfer RNA proline (anticodon AGG) 89 Neighboring gene uncharacterized LOC120094336 Neighboring gene U4 spliceosomal RNA Neighboring gene layilin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. [Effects of SIK2 on mitochondrial energy metabolism in rats with myocardial ischemia/reperfusion injury and its mechanisms]. Xu L, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2022 Jul. PMID 36414551
    2. Salt-inducible kinase 2 regulates energy metabolism in rats with cerebral ischemia-reperfusion. Zhang R, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2021 Jun 25. PMID 34402252, Free PMC Article
    3. SIK2 is involved in the negative modulation of insulin-dependent muller cell survival and implicated in hyperglycemia-induced cell death. Küser-Abali G, et al. Invest Ophthalmol Vis Sci, 2013 May 1. PMID 23599336
    4. Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats. Liu Y, et al. Endocrinology, 2012 Jan. PMID 22109884, Free PMC Article
    5. Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. Hashimoto YK, et al. J Cell Biochem, 2008 Aug 1. PMID 18348280

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Effects of SIK2 on mitochondrial energy metabolism in rats with myocardial ischemia/reperfusion injury and its mechanisms].
      Title: [Effects of SIK2 on mitochondrial energy metabolism in rats with myocardial ischemia/reperfusion injury and its mechanisms].
    2. Salt-inducible kinase 2 regulates energy metabolism in rats with cerebral ischemia-reperfusion.
      Title: Salt-inducible kinase 2 regulates energy metabolism in rats with cerebral ischemia-reperfusion.
    3. Results indicate that SIK2 functions as a negative modulator of the insulin-dependent survival pathway and contributes to hyperglycemia-induced cell death of Muller glia.
      Title: SIK2 is involved in the negative modulation of insulin-dependent muller cell survival and implicated in hyperglycemia-induced cell death.
    4. SIK2 mediates TORC2 inactivation in basal conditions, whereas induction of SIK1 limits transcriptional activation in the hypothalamic paraventricular nucleus
      Title: Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription from RNA polymerase II promoter by glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine-protein kinase SIK2
    Names
    SNF1-like kinase 2
    NP_001414257.1
    XP_056840514.1
    XP_056840515.1
    XP_056840516.1
    XP_056840517.1
    XP_056840518.1
    XP_056840519.1
    XP_063121520.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427328.1 → NP_001414257.1  serine/threonine-protein kinase SIK2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      Q3LRT3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      60121913..60221707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_056984536.2 → XP_056840516.1  serine/threonine-protein kinase SIK2 isoform X4

      UniProtKB/TrEMBL
      Q3LRT3

    2. XM_056984535.2 → XP_056840515.1  serine/threonine-protein kinase SIK2 isoform X2

      UniProtKB/TrEMBL
      Q3LRT3

    3. XM_063265450.1 → XP_063121520.1  serine/threonine-protein kinase SIK2 isoform X3

      UniProtKB/TrEMBL
      Q3LRT3
      Related
      ENSRNOP00000087049.2, ENSRNOT00000119371.2

    4. XM_056984534.2 → XP_056840514.1  serine/threonine-protein kinase SIK2 isoform X1

      UniProtKB/TrEMBL
      Q3LRT3
      Related
      ENSRNOP00000062018.3, ENSRNOT00000066893.5

    5. XM_056984537.2 → XP_056840517.1  serine/threonine-protein kinase SIK2 isoform X5

      UniProtKB/TrEMBL
      A6J4G6
      Related
      ENSRNOP00000068754.3, ENSRNOT00000091732.3

    6. XM_056984538.1 → XP_056840518.1  serine/threonine-protein kinase SIK2 isoform X6

      UniProtKB/TrEMBL
      A6J4G6
      Related
      ENSRNOP00000109973.1, ENSRNOT00000143737.1

    7. XM_056984539.2 → XP_056840519.1  serine/threonine-protein kinase SIK2 isoform X7

      UniProtKB/TrEMBL
      A6J4G6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.