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    Rd3 RD3 regulator of GUCY2D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684158, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rd3provided by RGD
    Official Full Name
    RD3 regulator of GUCY2Dprovided by RGD
    Primary source
    RGD:1593897
    See related
    EnsemblRapid:ENSRNOG00000050766 AllianceGenome:RGD:1593897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including negative regulation of guanylate cyclase activity; retina development in camera-type eye; and visual perception. Predicted to be located in several cellular components, including perinuclear region of cytoplasm; photoreceptor inner segment; and photoreceptor outer segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 12; and retinal degeneration. Orthologous to human RD3 (RD3 regulator of GUCY2D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 4.1), Lung (RPKM 3.0) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Rd3 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (106060657..106097063)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (103551823..103562925)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110739645..110749167)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352598 Neighboring gene uncharacterized LOC120096357 Neighboring gene TNF receptor-associated factor 5 Neighboring gene REST corepressor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in negative regulation of guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retina development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cone photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rod photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RD3 regulator of GUCY2D; protein RD3
    Names
    retinal degeneration 3, GUCY2D regulator

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428897.1NP_001415826.1  RD3 regulator of GUCY2D

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JH06, M0R688

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      106060657..106097063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272732.1XP_063128802.1  protein RD3 isoform X1

    2. XM_063272733.1XP_063128803.1  protein RD3 isoform X2

      Related
      ENSRNOP00000099874.1, ENSRNOT00000139943.1
    3. XM_039091509.2XP_038947437.1  protein RD3 isoform X1

      UniProtKB/TrEMBL
      A6JH06, M0R688
      Related
      ENSRNOP00000064931.1, ENSRNOT00000075086.4
      Conserved Domains (1) summary
      pfam14473
      Location:8133
      RD3; RD3 protein