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    ctf-8 Ctf8 [ Caenorhabditis elegans ]

    Gene ID: 188728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctf-8
    Official Full Name
    Ctf8
    Primary source
    WormBase:WBGene00011915
    Locus tag
    CELE_T22C1.4
    See related
    AllianceGenome:WB:WBGene00011915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in mitotic sister chromatid cohesion. Predicted to be located in nucleus. Predicted to be part of Ctf18 RFC-like complex. Orthologous to human CHTF8 (chromosome transmission fidelity factor 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ctf-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (7940134..7940728, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Myosin-11 Neighboring gene UBR-type domain-containing protein Neighboring gene Globin-like protein 26 Neighboring gene GPI transamidase component GAB1 Neighboring gene TFIIIC_sub6 domain-containing protein Neighboring gene Transport and Golgi organization protein 1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target. McLellan J, et al. Mol Biol Cell, 2009 Dec. PMID 19846659, Free PMC Article
    2. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ctf18 RFC-like complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ctf8
    NP_492190.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7940134..7940728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059789.6 → NP_492190.2  Ctf8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492190.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22664
      Conserved Domains (1) summary
      pfam09696
      Location:48 → 105
      Ctf8; Ctf8
    Nucleotide Protein
    Heading Accession and Version

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