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    glct-4 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 183560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glct-4
    Official Full Name
    Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
    Primary source
    WormBase:WBGene00008160
    Locus tag
    CELE_C47F8.4
    See related
    AllianceGenome:WB:WBGene00008160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Predicted to be involved in carbohydrate metabolic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus and schizophrenia. Orthologous to human B3GAT1 (beta-1,3-glucuronyltransferase 1) and B3GAT2 (beta-1,3-glucuronyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glct-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (12317321..12318735, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Acyl_transf_3 domain-containing protein Neighboring gene Hexosyltransferase Neighboring gene Hexosyltransferase Neighboring gene Hexosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
    NP_493114.2
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12317321..12318735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060713.2 → NP_493114.2  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493114.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62113
      Conserved Domains (1) summary
      cd00218
      Location:53 → 282
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
    Nucleotide Protein
    Heading Accession and Version

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