U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Poldip2 DNA polymerase delta interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287544, updated on 3-Dec-2024

    Summary

    Official Symbol
    Poldip2provided by RGD
    Official Full Name
    DNA polymerase delta interacting protein 2provided by RGD
    Primary source
    RGD:1307022
    See related
    EnsemblRapid:ENSRNOG00000009252 AllianceGenome:RGD:1307022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PDIP38
    Summary
    Predicted to enable DNA binding activity. Involved in several processes, including positive regulation of Rho guanyl-nucleotide exchange factor activity; positive regulation of focal adhesion assembly; and vascular associated smooth muscle cell proliferation. Located in cell-cell junction; midbody; and mitotic spindle. Orthologous to human POLDIP2 (DNA polymerase delta interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 735.3), Muscle (RPKM 606.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Poldip2 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63905287..63915655)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63407237..63417605)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65781994..65790833)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SEBOX homeobox Neighboring gene transmembrane protein 199 Neighboring gene TNF alpha induced protein 1 Neighboring gene intraflagellar transport 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polymerase delta-interacting protein 2
    Names
    DNA-directed polymerase delta interacting protein 2
    polymerase (DNA) delta interacting protein 2
    polymerase (DNA-directed), delta interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401983.1NP_001388912.1  polymerase delta-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A984, C8YL70, E9PT51
      Related
      ENSRNOP00000013100.7, ENSRNOT00000013100.9
      Conserved Domains (2) summary
      cl01119
      Location:234355
      DUF525; ApaG domain
      cl01548
      Location:74200
      YccV-like; Hemimethylated DNA-binding protein YccV like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63905287..63915655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105816.1: Suppressed sequence

      Description
      NM_001105816.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.